Download Neoplastic Transformation in Human Cell Culture: Mechanisms by J. Carl Barrett (auth.), Johng S. Rhim, Anatoly Dritschilo PDF

By J. Carl Barrett (auth.), Johng S. Rhim, Anatoly Dritschilo (eds.)

The position of carcinogenic brokers within the deveolopment of human cancers is now being outlined utilizing numerous human cells as experi­ psychological version structures. A workshop on "neoplastic transformation in human cellphone structures in vitro: mechanisms of carcinogenesis" used to be held on the Georgetown collage clinical heart, Washington, DC, on April 25-26, 1991. The goals of the workshop have been to give the state-of-the­ artwork within the transformation of human cells in tradition, in addition to to supply perception into the molecular and mobile adjustments eager about the conver­ sion of standard cells to a neoplastic kingdom of development. the next subject matters have been heavily relating to the subject of the workshops: 1. Derivation of in vitro version platforms (epithelial, fibroblastic, and hematopoietic). 2. elements modulating mobile transformation. three. Usefulness of outlined in vitro version structures for viral, chemical, and radiation carcinogenesis. four. Multistep nature of human cellphone carcinogenesis. five. function of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was once geared up via J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. there have been 32 audio system, 30 poster shows, and approximately a hundred ninety participants.

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Neoplastic Transformation in Human Cell Culture: Mechanisms of Carcinogenesis

The position of carcinogenic brokers within the deveolopment of human cancers is now being outlined utilizing a number of human cells as experi­ psychological version structures. A workshop on "neoplastic transformation in human mobile platforms in vitro: mechanisms of carcinogenesis" used to be held on the Georgetown collage scientific heart, Washington, DC, on April 25-26, 1991.

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Sanford and R. , Washington, DC 20059 USA The following three factors appear to be necessary for the malignant neoplastic transformation of normal cells in culture or in vivo: 1) DNA damage, 2) deficient DNA repair during G2 phase of the cell cycle and 3) a continued proliferative stimulus from activation of protooncogenes or loss of suppressor genes. Continued cell proliferation alone leads to hyperplasia and benign growths. Deficient repair of DNA damage provides the genomic instability that can result in production of new genetic variants characterizing malignant neoplasia.

Brondyk, Hua-Ming Jin, Craig W. Stevens, Carsten-Peter Carstens, Gregory C. Kujoth and Helen L. , anchorage-independent growth; refs. 1-5), a phenotype, which aside from some hematopoeitic cells, is rarely observed in nonneoplastic human cells. Treatment of rodent or human fibroblasts with mutagens has been shown to induce anchorageindependent growth at frequencies consistent with mutation at a single, dominant-acting gene (6,7), or perhaps pool of genes, any locus of which is permissive for the phenotype in its mutant form.

Endo, and J. Massague. 262, 6443-6446 (1987). J. BioI. Chem. 11. P. Penttinen, S. Kobayashi, and P. Bornstein. Proc. Nat1. Acad. Sci. , 85, 1105-1108 (1988). 12. C. M. Watt. Nature 340, 307-309 (1989). 13. C. M. Watt. Cell 63, 425-435 (1990). 14. H. Zur Hausen. Cancer Res. 49:4677-4681 (1989). : J. S. Rhim and A. , Totowa, NJ S'l'UDIES OF MUTAGEN-ACTIVATED GENES WHICH CONFER ANCHORAGE-INDEPENDENCE: THE c-lIill GKNI: AS A MODEL William E. Fahl, william H. Brondyk, Hua-Ming Jin, Craig W. Stevens, Carsten-Peter Carstens, Gregory C.

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