By Herbert E. Spiegel
This quantity, edited for the final time via H.E. Spiegel, maintains the target of increasing the highbrow horizon of scientific chemistry. The fields of analytical, anatomical, sub-cellular and molecular sciences are all represented during this quantity. * unique experiences through working towards scientists * Covers a wide variety of scientific chemistry on a theoretical and sensible foundation * contains effortless to learn chapters combining technology and views in a altering clinical panorama
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Extra info for Advances in Clinical Chemistry, Vol. 37
2. CHEMOKINES AND DISEASES Chemokines have been shown to play an important role in the following types of diseases: allergic reaction, cardiovascular disease, neurological disorder, transplantation reactions, and viral infection. 1. Allergic Disease Chemokines have been implicated in diverse pathophysiological functions in allergic inﬂammation including chemoattraction, cellular activation, hematopoiesis, homeostatic role, and modulation of T cell immune response (R6). 1. Chemoattraction. The interaction between leukocytes in the circulation and endothelial cells lining blood vessels is a complex network of signaling events regulating trafﬁcking of particular leukocyte subsets (B19).
0 pg/ml per hour range of GM-CSF. Therefore, GM-CSF produced from T cells may be used as a marker for the suppression of T cells activation in viral infection (C14). 32 WONG AND LAM 5. Conclusions Cytokine research is a rapidly expanding ﬁeld of immunology, cell biology, and allergy research. The explosion of knowledge in the immunobiology of cytokines can help us to identify novel cytokines, evaluate the detailed roles of cytokines in the pathogenesis of many diseases, and elucidate the detailed intracellular signal transduction mechanisms of different cytokines.
England, B. , Chen, M. , Schatz, P. , Chen, Y. , Whitehorn, E. , Martens, C. , Barrett, R. , A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains. Proc. Natl. Acad. Sci. USA 97, 6862–6867 (2000). E7. Evans, S. , and Whicher, J. , The cytokines: Physiological and pathophysiological aspects. Adv. Clin. Chem. 30, 1–88 (1993). F1. Favata, M. , Horiuchi, K. , Manos, E. , Daulerio, A. , Stradley, D. , Feeser, W. , Van Dyk, D. , Pitts, W. , Earl, R. , Copeland, R.